FEN1 and central nervous system cancer: However, previous reports have demonstrated that the down‐regulation of FEN1 can increase the sensitivity of cisplatin in LN308 glioma cells and SGC‐7901 gastric cancer cell (Nikolova et al., 2009; Xie et al., 2016), implying the involvement of FEN1 in the repair of cisplatin‐induced DNA damage.