For example, SMYD3‐mediated AKT methylation at lysine 14 plays pivotal roles in activation of the AKT signaling pathway in breast and colon cancers,16 and PRMT1‐mediated methylation at arginine 887 of INCENP promotes mitosis of lung and cervical cancers.39 This evidence concerns the gene SMYD3 and malignant colon neoplasm.