Transfection of WT EML4‐ALK or K1451A‐, K1455A‐, or K1451A/K1455A‐subsituted EML4‐ALK showed a slight increase of phosphorylation levels of AKT at serine 473 and some tendency of growth promotion for both cancer cells (not statistically significant). This evidence concerns the gene AKT1 and cancer.