XDH and tuberculosis: First, we focus on the conversion of nitriles to their corresponding amides using nitrile hydratase (NHase) (Scheme 1 a), a class of enzyme extensively used in chemical synthesis within various industries—with acrylamide, nicotinamide (vitamin B3) and pyrazinamide (anti‐tuberculosis agent) being notable examples.14 Second, to illustrate multiple reaction steps, we have applied the method to xanthine oxidase (XO) catalysed biotransformations (Scheme 1 b).