These data suggest a novel role for Annexin VI in the regulation of calcium homeostasis and MV release in CAVD, building on previous reports demonstrating a specificity of Annexin V for macrophage‐derived MVs (New et al., 2013) and Annexin VI for VSMC‐derived MVs (Chen et al., 2008; Kapustin et al., 2011) in aortic calcification. Here, ANXA6 is linked to calcification.