TGFB1 and familial pancreatic carcinoma: Till now, large numbers of miRNAs are implicated in the pathogenesis and progression of pancreatic cancer, including KRAS-related miRNAs (e. g. miR-217), TGF-β-related miRNAs (e. g. miR-483), miR-155, miR-21, miR-34 and so on[28].