LRP5 and osteoporosis: SNP rs3736228 acts as potential eQTL cis-effect on CPT1A and and MTL5. Therefore, we speculate that rs3736228 plays important roles in the pathological mechanism of osteoporosis by regulating differential mRNA transcriptions of CPT1A and MTL5. On the other hand, since rs3736228 caused a missense mutation for LRP5 protein, LRP5 rs3736228 may influence and even induce osteoporosis through changing the amino acid sequence and secondary structure of LRP5 protein.