The elevation of c-Myc level markedly increases both metastasis and invasion capabilities of tumors[12–15].Although the direct activation of cyclin D1 by CREPT had been proved in colon cancer, our present studyonly verified the correlationship between the decreased expression of cyclin D1 and the knocking-down of CREPT both in vitro and in vivo cases of OSCC. The gene discussed is CCND1; the disease is malignant colon neoplasm.