First, we investigated the possibility of ANXA10 as a serum indicator for pancreatic diseases and evaluated ANXA10 levels in serum of patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), intraductal papillary mucinous neoplasm (IPMN), and healthy donors by ELISA assay. This evidence concerns the gene ANXA10 and pancreatic ductal adenocarcinoma.