First, we investigated the possibility of ANXA10 as a serum indicator for pancreatic diseases and evaluated ANXA10 levels in serum of patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), intraductal papillary mucinous neoplasm (IPMN), and healthy donors by ELISA assay. The gene discussed is ANXA10; the disease is pancreatic intraductal papillary-mucinous neoplasm.