TSPAN8 and colorectal neoplasm: Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo and inhibit the growth of colorectal tumors in a xenogeneic nude mouse model7, 11, 12 and significantly reduce incidence of epithelial ovarian cancer metastasis in vivo.