The screening and exploitation of small-molecule agents, which reduce the expression of cyclin D1, is expected for anticancer treatments and chemoprevention.23, 24, 25 Various natural compounds also have been reported to downregulate cyclin D1 in cancer cells.22, 26, 27, 28 We herein found that sesaminol, a sesame lignan from sesame oil, accumulated cells in G1 phase and pleiotropically reduced the expression of cyclin D1 at the mRNA and protein levels with mTORC1 inhibition and protein degradation. This evidence concerns the gene CCND1 and cancer.