EGFR and cancer: In proliferative cells including cancer cells, ANT2 is overexpressed as an oncoprotein.33, 34, 35 For example, the suppression of ANT2 has been shown to upregulate phosphatase and tensin homolog34 and tumor necrosis factor-related apoptosis-inducing ligand receptor,40, 46 or downregulate heat-shock protein 90,34 epidermal growth factor receptor,34 Ras,47 HER2,48 phophorylated Akt49 and ABCG2.36 In our study, we first showed that ANT2 could regulate cyclin D1 expression levels in various cancer cells.