FZD7 and neoplasm: Microarray analysis determined that FZD7 expression is upregulated in TNBC tissue and cell lines, and promotes tumorigenesis via canonical Wnt signaling pathways.123 Short hairpin RNA-mediated silencing of FZD7 reduced invasiveness and colony formation in TNBC cell lines.123 A recent study found that ΔNp63, an isoform of Transformation-related protein 63 (p63), enhanced FZD7 expression and increased Wnt signaling in TNBC tumor tissue and cell lines.124