Gene expression analyses found that LRP6 is overexpressed in human TNBC.123, 131In vivo studies have shown that LRP6 silencing inhibited tumor growth in TNBC cell line-derived xenograft models.132 LRP6 and Wnt target gene SOX9 have been shown to influence regulation of one another in TNBC cell lines. Here, LRP6 is linked to neoplasm.