A study recently found that knockdown of ΔNp63 in TNBC cell lines decreased FZD7 expression and tumorsphere formation, indicating that ΔNp63/FZD7 upregulation induced TNBC stem cells and promoted tumor formation in TNBC.124 The findings of this study highlight the potential clinical importance of ΔNp63/FZD7-Wnt signaling in TNBC stem cells as a key driver of tumorigenesis and progression of TNBC.124, 125. The gene discussed is FZD7; the disease is neoplasm.