At 24 h from the onset of AP symptoms, angiopoietin-2 at a cut-off value of 5.92 ng/mL predicted SAP with a diagnostic sensitivity of 100% and specificity of 92%; ISTH score at a cut-off value of 3 points predicted SAP with a diagnostic sensitivity of 100% and specificity of 81%; and D-dimer at a cut-off value of 6.55 μg/mL predicted SAP with a diagnostic specificity of 80% and sensitivity of 94% (Figure 4). Here, ANGPT2 is linked to alkaline phosphatase measurement.