BACE1 and early-onset autosomal dominant Alzheimer disease: For example, it has been shown that a lncRNA, β-site amyloid precursor protein cleaving enzyme-1 antisense transcript (BACE1-AS) is deregulated in Alzheimer’s disease (AD) which induces feed-forward regulation of BACE1, increases Aβ levels, and thus may promote the pathogenesis of AD [33,34].