Further studies investigating renal hemodynamics such as intra-renal sodium loading, renin-angiotensin system activation, and tubular glomerular feedback, in addition to renal injury markers, such as kidney injury molecule-1, liver fatty acid binding protein, and interleukin-1847, would add to our understanding of the mechanisms of hyperfiltration in the context of insulin resistance. This evidence concerns the gene REN and Insulin resistance.