WAS and immune system disorder: In Wiskott–Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT), mutations in WAS (encoding WASP) cause microthrombocytopenia (that is, reduced numbers and size of blood platelets), immunodeficiency, eczema, increased malignancies and autoimmune symptoms including vasculitis and inflammatory bowel disease5, 6, 7, 8.