VEGFA and cancer: 2016) and also inhibit VEGF-induced cell proliferation and migration in HUVECs, as well as angiogenesis (Wu et al. 2012). Also, the high phenolic content in the M. paradisiaca roots may be contributing to the anti-angiogenic, anti-proliferative and pro-apoptotic properties since phenols have been known to play a critical role in inhibition of VEGF, PDGF receptor phosphorylation, MMP inhibition, cell migration, inhibition of ROS (Sun et al. 2015) and also induction of apoptosis in cancer cells (Roy et al. 2002).