MED1 and neoplasm: Further, in NMIBC (NMIBC = pTis and pT1), the expression intensity of MED1 was similar compared to the benign transitional epithelium (Figure 1B, p = 0.99), whereas in muscle-invasive tumor stages (MIBC = T2–T4), the nuclear and cytoplasmic MED1 expression was significantly decreased compared to benign bladder tissue (Figure 1C, p = 5E−05).