The aim of this study was to investigate the expression of the intracellular and extracellular domains of EGFR, as well as its activated status and ligands in a large population-based series of human meningiomas with long follow-up data and the association with histopathological features, meningioma subtypes, malignancy grade, and risk of recurrence. This evidence concerns the gene EGFR and meningioma.