Moreover, Del Bon et al. discovered on univariate analysis that the rpT category had a statistically significant impact on local control with laser alone (100% for rpT1, 67% for rpT2, and 50% for rpT3), both in the entire cohort and in the group with true persistent and recurrent disease, excluding second primary glottic carcinomas in a previously irradiated area [17]. This evidence concerns the gene PSMC4 and glottis carcinoma.