We further examined the expression of tnfα as an inflammatory cytokine responsible for insulin resistance, as well as sirt1 and sod2 as targets genes of Vash1 in ECs, but we could not find any differences in their expression levels between WT mice and vash1−/− mice in their WAT (Figures 4(a) and 4(b)). This evidence concerns the gene SOD2 and Insulin resistance.