In fact, similar changes were reported in other animal models of RPE degeneration, including sodium iodate [7] and ornithine-induced models [10] and the ornithine delta-aminotransferase deficient mouse [11], and a similar scenario also has been invoked as a mechanism in human dry AMD [2, 3] and gyrate atrophy [4]. This evidence concerns the gene OAT and Gyrate atrophy of choroid and retina.