MGMT and glioblastoma: Furthermore, the NOA-08 trial and the Nordic Glioma trial both explored radiation therapy versus chemotherapy with temozolomide (TMZ) in two different elderly patients cohorts, both showing that alkylating chemotherapy is beneficial only in patients with GBM with methylated MGMT promoter, whereas radiotherapy also prolongs survival in patients whose tumors are unmethylated [17–19].