The proposed interlinked mechanisms to explain the relationship between serum UA and MetS apart from insulin resistance were oxidative stress [24], endothelial dysfunction [25], renal microvascular lesions [26], and the imbalance in vasodilation (reduction of nitric oxide [25]) and vasoconstriction (increase of renin-angiotensin-aldosterone-system [19]). The gene discussed is REN; the disease is metabolic syndrome.