TNF and sleep disorder: Vgontzas et al. found that IL-6 and TNF-α were related with lethargy and fatigue, and positively correlated with AHI, indicating that they were correlated with the sleep disorders of children with OSAHS.18 Ridker et al. reported that healthy subjects with elevated serum IL-6 levels were significantly more prone to future myocardial infarction, so IL-6 was an independent risk factor for predicting cardiovascular events.19 IL-10 and INF-γ are secreted by Th1 cells.