The incidence of women in the reproductive period is about 5%-10%, but its etiology has not been fully clear yet.5 Endocrine disorders are the main clinical features of patients with PCOS, mainly manifested as increase of LH, LH/FSH and T at varying degrees, of which the reason may be the increased pituitary sensitivity to gonadotropin-releasing hormones, resulting in excessive LH secretion. Here, PLOD1 is linked to endocrine system disorder.