Excessive LH can also stimulate theca cells and ovarian stroma to secret excessive androgen.6 Due to the above mechanisms, the ovarian androgen levels of PCOS patients were significantly higher than those of the normal women, and the follicle maturation process is inhibited, but the small follicles in the ovaries of patients can still secrete a certain amount of E2. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.