Decrease in insulin level lowers those of LH and androgen as well as LH/FSH, helps correct hirsutism and acne, and recovers ovulatory menstruation.15 Palomba et al.16 found that the cumulative ovulation rate using metformin was similar to that using clomiphene, but the former led to higher rates of pregnancy and live birth. This evidence concerns the gene BRD2 and acne.