ALDH5A1 and tuberous sclerosis: [However, the situation may not be so simple, as mTOR is upregulated by the excessive GABA present when the gene for succinic semialdehyde dehydrogenase is knocked out in mice (mimicking human SSADH deficiency) (30).] Since infants with TSC have such a high risk for developing infantile spasms, a novel approach is to treat infants who have epileptiform abnormalities on EEG (but no documented seizures) prophylactically with vigabatrin before spasms begin (31, 32).