Another report discovered an interaction between an α2A-AR gene SNP and a specific methylenetetrahydrofolate reductase gene SNP, which encodes for an enzyme involved in DNA methylation, in patients with schizophrenia (53), suggesting a potential role for NE in the epigenetic control relevant to the pathogenesis of schizophrenia. This evidence concerns the gene MTHFR and schizophrenia.