When we performed heat-map analysis for the normalized dataset for some of the PSP/CBD associated genes (PAXIP1, SOS1, DYSF, EIF2AK3, STX6, ABCA7, MOBP, and MAPT) in our whole genome screen, we noticed a very clear segregation of hTauMaptKO(Duke) and WT mice (Supplementary Figure S6). This evidence concerns the gene EIF2AK3 and supranuclear palsy, progressive, 1.