Downregulation of PAX2 via siRNA in A498 (renal carcinoma), EAhy (endothelial), T98G (glioblastoma), and SKOV3ip (ovarian carcinoma) cells revealed a nearly total loss of ADAM10 protein as demonstrated by Western blot analysis (Doberstein et al., 2011). This evidence concerns the gene ADAM10 and glioblastoma.