In addition, the Tcf/Lef-family of transcription factors which is known to interact with beta-catenin (Wisniewska, 2013) also seems to be involved: Wang et al. demonstrated in transgenic AD mice the induction of Wnt signaling by huperzine A. This was accompanied by elevated beta-catenin levels and increased ADAM10 protein levels (Wang et al., 2011). This evidence concerns the gene CTNNB1 and Alzheimer disease.