However, Klein and colleagues demonstrated no significant association between CRP plasma concentration and AMD or AMD progression in both case-control and prospective studies.(34) In a case-control study using patients recruited from Muenster (Germany), researcher found significantly elevated CRP levels as the degree of AMD severity increased compared with controls,(35) but when cardiovascular risk factors were taken into consideration no statistically significant increases were found with ORs of AMD patients compared with controls.(35). Here, CRP is linked to age-related macular degeneration.