The aim of this study was to analyze the activities of antioxidant enzymes: SOD, GR, and GPx, along with the non-enzymatic low molecular substances (albumin, uric acid and bilirubin) and the Total Antioxidant Status (TAS) of serum, as well as the acute inflammatory markers (CRP, IL-6 and fibrinogen) in patients with AMD. The gene discussed is GSR; the disease is age-related macular degeneration.