Additionally, recent studies have shown that MTUS1 loss or downregulation is associated with enhanced tumor proliferation, poor tumor differentiation, and poor prognosis in bladder cancer (Xiao et al., 2012), gastric cancer (Li et al., 2014a), salivary adenoid cystic carcinoma (Zhao et al., 2015), and other cancers (Louis et al., 2010; Louis et al., 2011; Ding et al., 2012; Varghayee et al., 2015). This evidence concerns the gene MTUS1 and urinary bladder cancer.