Capsaicin-elicited Ca2+ did not induce mast cell degranulation but triggered the release of IL-4 (Bíró et al., 1998), which is known to be involved in AD associated with the recruitment of neutrophils, macrophages, CD3+ lymphocytes, and epidermal dendritic T lymphocytes (Zhao et al., 2016). The gene discussed is IL4; the disease is Alzheimer disease.