Indeed, in acute oxazolone-induced dermatitis in mouse ears, TRPA1-deficient mice or WT mice treated with the TRPA1 antagonist HC-030031 showed diminished skin inflammation, which was associated with a decrease in ear epidermal thickness, eosin-positive cells, and CD4+ and CD8+ T cells in the ear tissue. The gene discussed is TRPA1; the disease is skin disorder.