CD4 and congenital secretory chloride diarrhea 1: In ALF patients, there is an increase in the proportion of circulating CD4+ T cells (median 64.01%; IQR, 56.51%−71.61%) when compared to healthy (47.17%; 45.17%−58.12%) (P = .003) and pathologic controls (CLD 65.64%; IQR, 51.9%−74.07%), ACLF (57.30%; IQR, 46.54%−69.56%), and sepsis patients (70.18%; IQR, 58.61%−77.11%) (Figure 1A).