This study found a positive correlation between PAI-1 and ICAM-1 (P < 0.05, r = 0.689) at both time points, demonstrating an association between markers of endothelial activation and fibrinolysis, showing that increased expression of ICAM-1 and PAI-1 might be a result of the proinflammatory state in babesiosis. This evidence concerns the gene SERPINE1 and babesiosis.