Specifically, our main findings are that concentrations for markers of fibrinolysis (D-dimer, tPA, and PAI-1), endothelial activation (Ang-2, Ang-2/Ang-1 ratio, and vWF), extracellular matrix metabolism (tenascin C and TIMP-1) and tissue damage (TFF3, cystatin C, and NGAL) were increased in patients with HIV-tuberculosis who died, whereas concentrations of anticoagulant proteins (total and free protein S, ADAMTS-13 and antithrombin) were decreased. This evidence concerns the gene SERPINE1 and tuberculosis.