Previous studies have shown that pharmacological inhibition of ANO1 by small-molecule ANO1 inhibitors such as T16Ainh-A01, CaCCinh-A01, tannic acid, MONNA and idebenone significantly decreased cell proliferation, migration or invasion abilities in human cancer cell lines expressing ANO1, even though the pathophysiological roles of ANO1 in cancer and the underlying molecular mechanisms of anticancer effect of downregulation of ANO1 are not clearly understood [12, 13, 23, 24]. Here, ANO1 is linked to cancer.