In addition, ANO1 is amplified and highly expressed in a number of cancers, including prostate cancer, breast cancer, gastrointestinal stromal tumor (GIST), head-and-neck squamous cell carcinoma (HNSCC), and esophageal squamous cell carcinoma (ESCC), and involved in cancer cell proliferation, tumorigenesis and cancer progression [6–10]. This evidence concerns the gene ANO1 and gastrointestinal stromal tumor.