Moreover, MPiφs express high levels of two interleukin receptors: 1) IL-7R (∼18-fold), which is associated with several diseases including multiple sclerosis, rheumatoid arthritis and juvenile idiopathic arthritis; and 2) interleukin-1 receptor-like 2 (10.8-fold), which is unable to bind IL-1α with high affinity. Here, IL1A is linked to juvenile idiopathic arthritis.