We hypothesized that the severe anemia of fascioliasis infection in the R8 group was due to Ifng increased expression in the absence of Tgfb or Il10. Examples of the role of Treg in reducing immunopathology can be found in the original observation of their role in control of colitis [92], reduction of pulmonary inflammation in pneumocystis [93], control of hepatic pathology in Schistosoma infections [94] or control of immunopathological lesions in viral infections [95]. This evidence concerns the gene IFNG and anemia (phenotype).