Decreased expression levels of RCCD1 (p-value: 3.6x10-06) and DHODH (p-value: 7.1x10-06) showed significant associations with breast cancer risk based on a Bonferroni-corrected significance threshold (0.05 / 4,473 = 1.1x10-05), and higher expression levels of ANKLE1 demonstrated a suggestive association (p-value: 9.3x10-05). The gene discussed is RCCD1; the disease is breast carcinoma.