PAGE4 and metastatic neoplasm: PAGE4 is a highly (~100%) intrinsically disordered CTA (Figure 3 and Table 1) that bears the hallmarks of a proto-oncogene; thus, it is highly expressed in the fetal human prostate, is undetectable in the normal adult gland, but is aberrantly expressed in androgen-dependent primary PCa and not in androgen-independent metastatic disease [106,107,108].