BRCA2 and cancer: In the BRCA2-dependent manner, CEP55 forms CEP55-ALIX (ALG-2 interacting protein X, also known as programmed cell death 6 interacting protein) and CEP55-TSG101 (another component of the ESCRT-1 (endosomal sorting complex required for transport-1) complex) complexes during abscission, whereas cancer-associated mutations in BRCA2 disrupts these interactions leading to the enhanced cytokinetic defects [144].