Although the authors evaluated PAGE4 as a biomarker to discern symptomatic and asymptomatic benign prostate hypertrophy (BPH), it is plausible that serum PAGE4 levels could discern PCa from normal and hence substitute for PSA given that, in the adult human male, PAGE4 is remarkably prostate-specific marker and is undetectable in the normal adult prostate [108,147]. Here, KLK3 is linked to benign prostatic hyperplasia.