Based on the TCGA exome set, we observe a significantly decreased survival for head and neck cancer (HNSC) samples mutated in the promoter region of PRSS3 (p=1.8 × 10−3, Log-rank test) (Figure 7B) as well as in the PRSS3 coding gene (p=1.2 × 10−2, Log-rank test). Here, PRSS3 is linked to head and neck cancer.