There is a tendency for an increased value of the uracil-DNA glycosylase deficiency signature statistic in SMUG1 mutated melanoma samples (p=8.2 × 10−2, one-sided Wilcoxon rank sum test), and a significantly increased value of this statistic for the one SMUG1 mutated uterus cancer sample (p=2.1 × 10−2, one-sided Wilcoxon rank sum test), compared to samples not harbouring a SMUG1 mutation (Figure 6C). Here, SMUG1 is linked to melanoma.