Combined analyses (Table 3) revealed that having a positive or unknown family history of diabetes was highly associated with increased prevalence of diabetes in each serum hs-CRP level (≤median and >median) and elevated serum hs-CRP level (>median) was also associated with increased prevalence of diabetes in both subjects without a family history of diabetes and those having a positive or unknown family history. This evidence concerns the gene MAP3K14 and diabetes mellitus.