NFKB1 and viral infectious disease: Taken together, we supposed that both LvFLp53 and LvΔNp53 could modulate NF-κB mediated immune response by targeting to the NF-κB transcription factor LvDorsal, which induced the change of LvDorsal activity and thus resulted in different immune response to bacterial and viral infection (Fig. 5E, See details in discussion).