INS and Hyperglycemia: Our results can be summarized as follows: (i) we show that TRPM5 is essential for the biological action of steviol and SGs; (ii) we show that potentiation of TRPM5 ion channel activity by SGs modulates taste responses and insulin release; and (iii) potentiation of TRPM5 activity protects mice against the development of HFD-induced hyperglycaemia.