Indeed, a report by Liu et al. 23 indicates that SUV39H1 deficiency circumvents premature ageing in Zmpste24−/− mice that model the Hutchinson–Gilford progeria syndrome in humans, offering strong support for the argument that SUV39H activity promotes ageing and ageing-associated organ dysfunctions such as dementia and MI. The gene discussed is SUV39H1; the disease is dementia.