CSNK1G3 and Global developmental delay: 1970). Some reports have suggested severe problems associated with this disease including developmental delay and neurological problems (Meissner and Mayatepek 1997). Casein kinase 1 gamma 3 (CSNKIG3) encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. This gene plays an important role in basic human metabolic processes (Davidson et al. 2005).