Reactive oxygen species–PKD1 signaling has emerged to be important in the pathophysiology of neurodegenerative diseases (30, 31), cardioprotection against ischemia/reperfusion injury (19), tissue inflammation (32), and several cancers, including basal cell carcinoma (33) and pancreatic cancer (14, 34). This evidence concerns the gene PKD1 and familial pancreatic carcinoma.