Recently, 18F-AV-1451 was reported by Marquié et al. to bind tau lesions composed primarily of paired helical filaments in AD brains, without significant selectivity for straight tau filaments in 4-repeat tauopathies, or to lesions containing β-amyloid, α-synuclein, or TDP-43 aggregates [181, 182]. Here, MAPT is linked to Alzheimer disease.