There were several mouse models of neurodegeneration like AD studying the modulating effects of environmental factors: transgenic mice overexpressing amyloid precursor protein (APP) and/or presenilin (PS)-1, AD11 mice expressing anti-nerve growth factor (NGF) antibodies and double transgenic TgCRND8 mice overexpressing the Swedish and Indiana mutations in the human APP. Here, APP is linked to Alzheimer disease.