ICAM1 and obesity due to melanocortin 4 receptor deficiency: For ICAM-1, methylation of CpG1 was inversely associated with PBF in boys; mean methylation was inversely associated with WC-z in boys; and the cross product p value between CpG1 and sex was significant for all three obesity-related outcomes, with opposite directions of associations for boys and girls (online supporting information, Additional file 3: Table S3, Additional file 4).